A total protein test can detect normal or abnormal protein levels, which can help diagnose medical conditions, such as kidney and liver diseases. Reference range: No monoclonal proteins detected. Affected patients have no M protein in their urine, no lytic bone lesions, no anemia, no hypercalcemia, and no renal disease. In blood cancers such as myeloma, the 'M' in 'M protein' stands for monoclonal. 3.0 g/dL = 30 g/L. The information from protein electrophoresis can provide clues that a disease or condition is affecting protein production or … Maybe nothing: It depends which peak is elevated. If a monoclonal protein is present, a precipitant will form at this phase. I had an IFE test done. related monoclonal protein (or M-protein), while others may express the result as 30 g/L of M-protein. A monoclonal protein is produced by the abnormal, cancerous or precancerous cells. M-protein is an antibody—or part of an antibody—that can show up in tests of your blood and/or urine, and its presence can mean different things. This abnormal protein is formed within your bone marrow, the soft, blood-producing tissue that … In some instances patients with monoclonal free light chains may have no detectable monoclonal band. Finally, the sample is washed to remove the proteins that do not precipitate and then stained, destained, and dried. Spikes in other places can mean multiple myeloma, so ask what protein band 1 is.If it's albumin, you're ok! Interpretation: No monoclonal band detected - Immunofixation did not identify any protein. PR ≥ 50% reduction of serum M-protein and reduction in 24 hours urinary M-protein by ≥90% or to < 200 mg/24 h If the serum and urine M-protein are unmeasurable,5 a ≥ 50% decrease in the difference between involved and uninvolved FLC levels is required in place of the M-protein criteria If serum and urine M-protein are not Smoldering multiple myeloma M-protein level is greater than 3 … ¡ This does not mean that the M-protein has increased ten-fold. Refer to Protein Chemistry Lab ext 80334. The first peak is albumin, which is simply the total amount of protein in your blood.If this alone is elevated, it can mean you are dehydrated. This is rare but has been observed. The results are equivalent, but are expressed in different units. So when the Serum Protein Electrophoresis (SPEP) test shows a spike in M protein, this is a sign of MM. excess of an abnormal immunoglobulin called monoclonal protein (or M protein). My rheumatologist said that the results were normal but didnt explain the meaning? It was generally believed that the PS20 and PS80 stabilize proteins primarily through interfacial competition. Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood.  Platelets Small substances in your blood that help the blood to form a … Last medically reviewed on May 29, 2019. One trace IgG Lambda monoclonal protein migrating in the GAMMA region. Protein electrophoresis is used to identify and measure the presence of abnormal proteins, the absence of normal proteins, and/or to detect various protein electrophoresis patterns associated with certain conditions, as found in blood, urine or other body fluids.. Serum protein electrophoresis is the easiest means of excluding the presence of a monoclonal protein and can detect bands of 0.5 gm/dL or less. There is no band visible on electrophoresis. The results stated. Visual examination of electrophoretic patterns by a pathologist is the most sensitive method of detecting monoclonal proteins since small bands may be obscured in densitometric scans.